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MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma.
- Source :
- Nanomedicine: Nanotechnology, Biology & Medicine; Nov2017, Vol. 13 Issue 8, p2507-2516, 10p
- Publication Year :
- 2017
-
Abstract
- Hepatocellular carcinoma (HCC) is a prevalent and lethal disease that is characterized by drug resistance. Doxorubicin (DOX) is a widely used chemotherapeutic drug and miR-375 has been shown to be a tumor suppressor in HCC. Here, we reported that miR-375 and DOX co-loaded into lipid-coated calcium carbonate nanoparticles (LCC-DOX/miR-375 NPs), enhanced the anti-tumor effects through combination therapy, and were highly effective in reversing drug resistance in HCC. LCC-DOX/miR-375 NPs were prepared by a reverse microemulsions method. In vitro , LCC-DOX/miR-375 NPs exhibited enhanced intracellular accumulation, pH-sensitive DOX release and potent cytotoxicity. In vivo , LCC-DOX/miR-375 NPs showed efficient antitumor effect both in xenograft and primary HCC murine models. Our results showed that the LCC-DOX/miR-375 nanoparticles provide a novel strategy to overcome the drug resistance and promote addictive effect between miR-375 and DOX in HCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15499634
- Volume :
- 13
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Nanomedicine: Nanotechnology, Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 125981106
- Full Text :
- https://doi.org/10.1016/j.nano.2017.05.010