Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii.

An endophytic Phomopsis fukushii was isolated from the rhizome of Paris polyphylla var. yunnanensis , Diaporthaceae family, and three new ( 1–3 ) and four known napthalene derivatives ( 4 – 7 ) were isolated from the fermentation products of this fungus. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1–3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with vancomycin as positive control. The results showed that compounds 1–3 showed good inhibitions with MCI valves of 4, 4 and 6 m g/mL, respectively. [ABSTRACT FROM AUTHOR]