Outcome of Acute Pancreatic and Peripancreatic Collections Occurring in Patients With Acute Pancreatitis.

Objective: To study the outcome of acute collections occurring in patients with acute pancreatitis Background: There are limited data on natural history of acute collections arising after acute pancreatitis (AP). Methods: Consecutive patients of AP admitted between July 2011 and December 2012 were evaluated by imaging for development of acute collections as defined by revised Atlanta classification. Imaging was repeated at 1 and 3 months. Spontaneous resolution, evolution and need for intervention were assessed. Results: Of the 189 patients, 151 patients (79.9%) had acute collections with severe disease and delayed hospitalization being predictors of acute collections. Thirty-six patients had acute interstitial edematous pancreatitis, 8 of whom developed acute peripancreatic fluid collections, of which 1 evolved into pseudocyst. Among the 153 patients with acute necrotizing pancreatitis, 143 (93.4%) developed acute necrotic collection (ANC). Twenty-three of 143 ANC patients died, 21 had resolved collections, whereas 84 developed walled-off necrosis (WON), with necrosis >30% (P = 0.010) and Computed Tomographic Severity Index score ⩾7 (P = 0.048) predicting development ofWON. Of the 84 patients with WON, 8 expired, 53 patients required an intervention and 23 weremanaged conservatively. Independent predictors of any intervention among all patientswere Computed Tomographic Severity Index score ⩾7 (P < 0.001) and interval between onset of pain to hospitalization >7 days (P = 0.04). Conclusions: Patients with severe AP and delayed hospitalization more often develop acute collections. Pancreatic pseudocysts are a rarity in acute interstitial pancreatitis. A majority of patients with necrotising pancreatitis will develop ANC, more than half of whom will developWON. Delay in hospitalization and higher baseline necrosis score predict need for intervention. [ABSTRACT FROM AUTHOR]