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Reducing harms from treatment. Sixteen years of surgery of the axilla for screen-detected breast cancers in Italy.

Authors :
Lazzaretti, Maria Grazia
Ponti, Antonio
Mano, Maria Piera
Barca, Alessandra
Casella, Denise
Frigerio, Alfonso
Giordano, Livia
Mantellini, Paola
Paduos, Adriana
Pitarella, Sabina
Ravaioli, Alessandra
Taffurelli, Mario
Tomatis, Mariano
Segnan, Nereo
Source :
Breast; Dec2018, Vol. 42, p15-22, 8p
Publication Year :
2018

Abstract

Abstract Objectives Available evidence on axillary surgery has accumulated dramatically in the last two decades in favor of less invasive care. The aim of this paper is to study 16-years trends in the surgical management of the axilla in a large population-based data set of screen-detected breast cancers in Italy and to document at what extent recommendations have been adopted in actual clinical care. Material and methods This is a retrospective cohort study documenting the surgical management of the axilla in primary breast cancer patients over time. We retrieved from the Italian database of screen-detected cancers 41213 cases diagnosed in women aged 50–69 between years 2000 and 2015 in twelve Italian Regions. Results In pN0 cases, an increasing trend (p < 0.001) in the number of patients who received sentinel lymph node biopsy (SLNB) as the only axillary staging procedure was observed. In pN + cases SLNB was the only staging procedure in an increasing number of patients (p < 0.001) especially since the publication of the ACOSOG-Z0011 paper. In ductal carcinoma in situ (DCIS) SLNB was more frequent in mastectomies and in high grade and large lesions. However, 45% of low grade, small DCIS over the whole time period had some form of axillary surgery. Conclusion This large series of screen-detected cases documents a strong time trend in the direction of reducing axillary surgery and hence potential harms from treatment. The continuing practice of SLNB in low risk DCIS is of concern in an era of increasing awareness towards overdiagnosis and overtreatment. Highlights • Invasiveness of axillary surgery decreased dramatically in the last two decades. • Completion ALND in N+ patients decreased since publication of the Z0011 paper. • Smaller size, low grade and ER + are inversely associated to completion ALND. • Sentinel lymph node biopsy in low risk DCIS shows large variation in use. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09609776
Volume :
42
Database :
Supplemental Index
Journal :
Breast
Publication Type :
Academic Journal
Accession number :
132607267
Full Text :
https://doi.org/10.1016/j.breast.2018.08.001