A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp.

Graphical abstract Highlights • A new rare 14-nordrimane sesquiterpenoid was isolated from endophytic Phoma sp. • The structure was elucidated by means of spectroscopic methods. • Compounds 1 and 2 exhibited antiviral activity against H1N1 influenza virus. Abstract A new rare 14-nordrimane-type sesquiterpenoid, named phomanolide (1), together with five known compounds, (–)-6-methoxymellein (2), 7-hydroxy-3, 5-dimethyl-isochromen-1-one (3), norlichexanthone (4), 6-methylsalicylic acid (5), and gentisyl alcohol (6), were obtained from the culture broth of an endophytic fungus Phoma sp. isolated from the roots of Aconitum vilmorinianum. The structure of compound 1 was established based on extensive spectroscopic analysis. Compound 1 was the first example of 14-nordrimane-type sesquiterpene up to now. Compounds 1 and 2 showed antiviral activities against influenza A virus (A/Puerto Rico/8/34, H1N1) with IC 50 values of 2.96 ± 0.64 and 20.98 ± 2.66 μg/mL, respectively. [ABSTRACT FROM AUTHOR]