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Serum Phosphorylated Neurofilament Heavy Subunit-H, a Potential Predictive Biomarker for Postoperative Cognitive Dysfunction in Elderly Subjects Undergoing Hip Joint Arthroplasty.
- Source :
- Journal of Arthroplasty; Aug2019, Vol. 34 Issue 8, p1602-1605, 4p
- Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>Postoperative cognitive dysfunction (POCD), which refers to a cognitive impairment subsequent to surgical procedures, is a common complication in the elderly subjects. This study aimed to investigate potential risk factors for POCD in elderly subjects undergoing hip joint arthroplasty.<bold>Methods: </bold>Consecutive elderly osteoarthritis patients who were scheduled to undergo hip arthroplasty under epidural anesthesia were enrolled into this single-center, prospective observational study. Serum phosphorylated neurofilament heavy subunit-H (pNF-H) was measured by the enzyme-linked immunosorbent assay method. A level of >70.5 pg/mL was accepted as pNF-H positivity. Neuropsychological assessment at baseline (1 day before the surgery) and postoperative day 7 was conducted. POCD was defined according to the calculated Z scores. Risk factors for POCD were evaluated by univariate and multivariate logistic regression analyses.<bold>Results: </bold>In final, 287 patients were enrolled, and 55 had suffered POCD within postoperative 7 days with an incidence of 19.2%. The final multiple logistic regression analysis revealed a higher pNF-H positivity was the only independent risk factor for POCD (odds ratio: 2.03, 95% confidence interval: 1.21-3.29, P = .012).<bold>Conclusions: </bold>Our results revealed an increased preoperative serum pNF-H expression was an independent risk factor for POCD development in elderly subjects undergoing hip joint arthroplasty, suggesting the close association between anatomical damage in central nervous system and POCD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08835403
- Volume :
- 34
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Journal of Arthroplasty
- Publication Type :
- Academic Journal
- Accession number :
- 137594389
- Full Text :
- https://doi.org/10.1016/j.arth.2019.03.073