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Local Injection of Growth Hormone for Temporomandibular Joint Osteoarthritis.

Authors :
Soo-Min Ok
Jin-Hwa Kim
Ji-Su Kim
Eun-gyo Jeong
Yang Mi Park
Hye-Mi Jeon
Jun-Young Heo
Yong-Woo Ahn
Sun-Nyoung Yu
Hae Ryoun Park
Kyung-Hee Kim
Soon-Cheol Ahn
Sung-Hee Jeong
Source :
Yonsei Medical Journal; Apr2020, Vol. 61 Issue 4, p331-340, 10p
Publication Year :
2020

Abstract

Purpose: Osteoarthritis (OA) of the temporomandibular joint (TMJ) elicits cartilage and subchondral bone defects. Growth hormone (GH) promotes chondrocyte growth. The aim of this study was to evaluate the efficacy of intra-articular injections of GH to treat TMJ-OA. Materials and Methods: Monosodium iodoacetate (MIA) was used to induce OA in the TMJs of rats. After confirming the induction of OA, recombinant human GH was injected into the articular cavities of rats. Concentrations of GH and IGF-1 were measured in the blood and synovial fluid, and OA grades of cartilage and subchondral bone degradation were recorded by histological examination and micro-computed tomography. Results: MIA-induced OA in the rat TMJ upregulated insulin-like growth factor-1 (IGF-1) rather than GH levels. GH and IGF-1 concentrations were increased after local injection of GH, compared with controls. Locally injected GH lowered osteoarthritic scores in the cartilage and subchondral bone of the TMJ. Conclusion: Intra-articular injection of GH improved OA scores in rat TMJs in both cartilage and subchondral bone of the condyles without affecting condylar bone growth. These results suggest that intra-articular injection of human GH could be a suitable treatment option for TMJ-OA patients in the future. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
05135796
Volume :
61
Issue :
4
Database :
Supplemental Index
Journal :
Yonsei Medical Journal
Publication Type :
Academic Journal
Accession number :
142484335
Full Text :
https://doi.org/10.3349/ymj.2020.61.4.331