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Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.

Authors :
Goldburg, Samantha R.
Strober, Bruce E.
Payette, Michael J.
Source :
Journal of the American Academy of Dermatology; May2020, Vol. 82 Issue 5, p1045-1058, 14p
Publication Year :
2020

Abstract

Hidradenitis suppurativa (HS) is an inflammatory disorder that is characterized by chronic deep-seated nodules, abscesses, fistulae, sinus tracts, and scars in the axilla, inguinal area, submammary folds, and perianal area. This disfiguring condition is accompanied by pain, embarrassment, and a significantly decreased quality of life. Although the mechanism of HS has not been entirely elucidated, lesion formation is believed to center around follicular hyperkeratosis within the pilosebaceous-apocrine unit. Recent research has provided new insight into the role of cytokines in the pathogenesis of HS, helping close some existing knowledge gaps in the development of this condition. The first article in this continuing medical education series reviews HS epidemiology, clinical presentation, and classification. We also provide an update on the most recent understanding of HS pathogenesis, including the central role of inflammatory cytokines and other contributing factors, such as genetics, hormones, and pathogenic microorganisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01909622
Volume :
82
Issue :
5
Database :
Supplemental Index
Journal :
Journal of the American Academy of Dermatology
Publication Type :
Academic Journal
Accession number :
142720519
Full Text :
https://doi.org/10.1016/j.jaad.2019.08.090