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Design and validation of a closed-loop, motor-activated auricular vagus nerve stimulation (MAAVNS) system for neurorehabilitation.

Design and validation of a closed-loop, motor-activated auricular vagus nerve stimulation (MAAVNS) system for neurorehabilitation.

Authors :
Cook, Daniel N.
Thompson, Sean
Stomberg-Firestein, Sasha
Bikson, Marom
George, Mark S.
Jenkins, Dorothea D.
Badran, Bashar W.
Source :
Brain Stimulation; May2020, Vol. 13 Issue 3, p800-803, 4p
Publication Year :
2020

Abstract

Studies have found that pairing vagus nerve stimulation (VNS) with motor activity accelerates cortical reorganization. This synchronous pairing may enhance motor recovery. To develop and validate a motor-activated auricular vagus nerve stimulation (MAAVNS) system as a potential neurorehabilitation tool. We created MAAVNS and validated its function as part of an ongoing clinical trial investigating whether taVNS-paired rehabilitation enhances oromotor learning. We compared 3 different MAAVNS EMG electrode configurations in 3 neonates. The active lead was placed over the buccinator muscle. Reference lead placements were orbital, temporal or frontal. The frontal reference lead produced the highest sensitivity (0.87 ± 0.07 (n = 8)) and specificity (0.64 ± 0.13 (n = 8)). Oral sucking reliably triggers MAAVNS stimulation with high confidence. EMG electrodes placed on target orofacial muscles can effectively trigger taVNS stimuli in infants in a closed loop fashion. • This novel, motor-activated auricular vagus nerve stimulation (MAAVNS) system pairs stimulation with motor activity. • MAAVNS is a closed-loop system that allows for uniform delivery of taVNS treatment across multiple operators. • MAAVNS is feasible and may become a promising tool for both adult and pediatric neuromodulation-based rehabilitation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1935861X
Volume :
13
Issue :
3
Database :
Supplemental Index
Journal :
Brain Stimulation
Publication Type :
Academic Journal
Accession number :
142930880
Full Text :
https://doi.org/10.1016/j.brs.2020.02.028