Back to Search Start Over

N-terminal [Glu]3 moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor.

Authors :
Yamamoto, Mizuki
Terada, Yuko
Motoyama, Takayasu
Shibata, Munehisa
Saito, Tsutomu
Ito, Keisuke
Source :
Bioscience, Biotechnology & Biochemistry; Jul2020, Vol. 84 Issue 7, p1497-1500, 4p
Publication Year :
2020

Abstract

γ-glutamyl peptides have been suggested to impart kokumi properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu]<subscript>(n=0-4)</subscript>-α-[Glu]<subscript>(n=0-3)</subscript>-Tyr. Our results suggest that N-terminal [Glu]<subscript>3</subscript> moiety is very important for hCaSR activities of γ-glutamyl peptides. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09168451
Volume :
84
Issue :
7
Database :
Supplemental Index
Journal :
Bioscience, Biotechnology & Biochemistry
Publication Type :
Academic Journal
Accession number :
144526463
Full Text :
https://doi.org/10.1080/09168451.2020.1743169