Back to Search Start Over

Lights and Shadows on the Ross Procedure: Biological Solutions for Biological Problems.

Authors :
Nappi, Francesco
Spadaccio, Cristiano
Acar, Christophe
El-Hamamsy, Ismail
Source :
Seminars in Thoracic & Cardiovascular Surgery; Winter2020, Vol. 32 Issue 4, p815-822, 8p
Publication Year :
2020

Abstract

The Ross procedure represents a valid option for aortic valve replacement in young adults and was repeatedly shown to restore survival to that of the age- and sex-matched general population. However, its major drawback relies in the risk of pulmonary autograft (PA) dilation, negative histological remodeling and need for reoperation. Several techniques and materials to reinforce the PA have been proposed. They mainly include Dacron, personalized external aortic root support with a polyethylene terephthalate mesh system, autologous aortic tissue and bioresorbable materials. Synthetic materials, despite widely used in cardiac surgery, have significant biocompatibility issues with the PA and their interaction with this living structure translates into negative remodeling phenomena and disadvantageous biomechanical behaviors. Conversely, biomaterials with tailored degradable profiles might be able to reinforce while integrating with the PA and enhance its remodeling capabilities. The recent advancement in this field are here discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10430679
Volume :
32
Issue :
4
Database :
Supplemental Index
Journal :
Seminars in Thoracic & Cardiovascular Surgery
Publication Type :
Academic Journal
Accession number :
147114091
Full Text :
https://doi.org/10.1053/j.semtcvs.2020.04.006