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Effect of hydroxychloroquine, azithromycin and lopinavir/ritonavir on the QT corrected interval in patients with COVID-19.
- Source :
- Journal of Electrocardiology; Jan2021, Vol. 64, p30-35, 6p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Administration of Hydroxychloroquine and Azithromycin in patients with coronavirus disease 2019 (COVID-19) prolongs QTc corrected interval (QTc). The effect and safety of Lopinavir/Ritonavir in combination with these therapies have seldom been studied.<bold>Objectives: </bold>Our aim was to evaluate changes in QTc in patients receiving double (Hydroxychloroquine + Azithromycin) and triple therapy (Hydroxychloroquine + Azithromycin + Lopinavir/Ritonavir) to treat COVID-19. Secondary outcome was the incidence of in-hospital all-cause mortality.<bold>Methods: </bold>Patients under treatment with double (DT) and triple therapy (TT) for COVID-19 were consecutively included in this prospective observational study. Serial in-hospital electrocardiograms were performed to measure QTc at baseline and during therapy.<bold>Results: </bold>168 patients (±66.2 years old) were included: 32.1% received DT and 67.9% received TT. The mean baseline QTc was 410.33 ms. Patients under DT and TT prolonged QTc interval respect baseline values (p < 0.001), without significant differences between both therapy groups (p = 0.748). Overall, 33 patients (19.6%) had a peak QTc and/or an increase QTc 60 ms from baseline, with a higher prevalence among those with hypokalemia (p = 0.003). All-cause mortality was similar between both strategy groups (p = 0.093) and high risk QTc prolongation was no related to clinical events in this series.<bold>Conclusions: </bold>DT and TT prolong the QTc in patients with COVID-19. Addition of Lopinavir/Ritonavir on top of Hydroxychloroquine and Azithromycin did not increase QTc compared to DT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00220736
- Volume :
- 64
- Database :
- Supplemental Index
- Journal :
- Journal of Electrocardiology
- Publication Type :
- Academic Journal
- Accession number :
- 148726960
- Full Text :
- https://doi.org/10.1016/j.jelectrocard.2020.11.012