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Clinical Outcomes of Male Subjects With Moderate COPD Based on Maximum Mid-Expiratory Flow.
- Source :
- Respiratory Care; Mar2021, Vol. 66 Issue 3, p442-448, 7p
- Publication Year :
- 2021
-
Abstract
- BACKGROUND: Although FEV<subscript>1</subscript> and FEV<subscript>1</subscript>/FVC are accepted as standard parameters in treatment follow-up, these parameters have a limited ability to predict clinical outcomes in patients with COPD. However, small airways dysfunction, which is determined by maximum mid-expiratory flow, is variable in the same stage of patients with COPD, even if their FEV<subscript>1</subscript> and FEV<subscript>1</subscript>/FVC are similar. The aim of this study was to compare pulmonary function, the severity of perceived dyspnea, the severity of fatigue, physical activity level, and health-related quality of life based on the severity of small airways dysfunction in male subjects with moderate COPD. METHODS: The study consisted of 96 subjects with moderate COPD. Pulmonary function tests, the distance achieved on the 6- min walk test, the modified Medical Research Council Dyspnea Scale, the International Physical Activity Questionnaire - short form, the Fatigue Severity Scale, the St George Respiratory Questionnaire, and Short Form 36 questionnaire were evaluated in all subjects. After calculating the mean percent of predicted maximum mid-expiratory flow for the entire sample, subjects were divided into 2 groups: below average (Group 1, n = 54 subjects) and above average (Group 2, n = 42 subjects). RESULTS: There were no differences between the groups in age, body mass index, cigarette consumption, percent of predicted FEV<subscript>1</subscript>, and FEV<subscript>1</subscript> /FVC (P = .55, .61, .19, .09, and .15, respectively). Scores from the Fatigue Severity Scale and the modified Medical Research Council dyspnea scale were significantly higher in Group 1 (P = .003 and P = .002, respectively); in addition, results from the 6-min walk test and the International Physical Activity Questionnaire - short form scores were significantly lower (P = .001 and P < .001, respectively). CONCLUSIONS: Increased small airways dysfunction led to increased perception of dyspnea and fatigue, as well as poor exercise capacity and health-related quality of life in male subjects with COPD. We suggest that it may be useful to consider the maximum mid-expiratory flow in addition to FEV<subscript>1</subscript> and FEV<subscript>1</subscript>/FVC in the treatment and follow-up of male patients with moderate COPD. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNG physiology
CROSS-sectional method
MULTIPLE regression analysis
RESPIRATORY measurements
PHYSICAL activity
DYSPNEA
SEVERITY of illness index
RESPIRATORY obstructions
T-test (Statistics)
OBSTRUCTIVE lung diseases
FORCED expiratory volume
QUALITY of life
QUESTIONNAIRES
DESCRIPTIVE statistics
CHI-squared test
FATIGUE (Physiology)
DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 00201324
- Volume :
- 66
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Respiratory Care
- Publication Type :
- Academic Journal
- Accession number :
- 148893295
- Full Text :
- https://doi.org/10.4187/respcare.07794