Antibodies toP. vivaxprotein studied in malaria-exposed subjects.

Investigates the HLA class II and antibody responses to circumsporozoite protein (CSP) repeats of Plasmodium vivax in individuals naturally exposed to malaria in Brazil. Prevalence of immunoglobulin G antibodies for each one of the P. vivax CSP repeats; Examination of the potential relationship between HLA-DQB1 allele profile and antibody response to the CSP repeats of P. vivax; Modulation of the antibody responses to the CSP repeats of P. vivax variants by HLA class II molecules in malaria naturally exposed individuals.