Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3).

Introduction and objective. The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). Material and methods. NK cell and T reg activity in the study patient were analysed using flow cytometry. Results. Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. Conclusions. Although vulvar cancer may influence immune cell activity, this issue merits further study. [ABSTRACT FROM AUTHOR]