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Dietary supplementation with Yucca schidigera extract alleviated heat stress-induced unfolded protein response and oxidative stress in the intestine of Nile tilapia (Oreochromis niloticus).
- Source :
- Ecotoxicology & Environmental Safety; Aug2021, Vol. 219, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- Heat stress due to global warming exerts deleterious effects on both humans and animals. However, nutritional strategies to reduce heat stress-induced intestinal mucosal barrier dysfunction and the underlying mechanisms remain largely unknown. In the present study, 240 tilapia were distributed into four treatment groups that were fed a basal diet supplemented with or without 0.1% Yucca schidigera extract under normal (28 °C) temperature or heat stress (36 °C) conditions for 2 weeks. Our results showed that tilapia exposed to heat stress resulted in growth arrest, intestinal dysfunction, oxidative damage, endoplasmic reticulum stress, and pro-inflammatory response, which were significantly relieved by yucca supplementation. The alleviative effect of Yucca schidigera extract was related to the down-regulation of mRNA expression of ubiquitin-proteasome system (Polyubiquitin, Proteasome 26S, Proteasome α5, Proteasome β3, and Ubiquitin-like 3) and inflammatory factors (tumor necrosis factor α, interleukin 1β, and interleukin 8), as well as the improved histological structure and activation of Hsp70 , nuclear factor erythroid 2-related factor 2 signaling, interleukin 10, lysozyme, complement 3, and acid phosphatase in the intestine of tilapia. Collectively, these results indicated that heat stress-induced growth arrest, intestinal dysfunction, and oxidative damage were alleviated by dietary supplementation with Yucca schidigera extract. This offers a nutritional way of improving the growth and intestinal health of tilapia exposed to a hot environment. • Yucca alleviated the retarded growth and intestinal damage of tilapia induced by heat stress. • Yucca attenuated the endoplasmic reticulum stress in the intestine of heat-stressed tilapia. • Yucca enhanced the antioxidation and innate immunity of tilapia under heat stress conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01476513
- Volume :
- 219
- Database :
- Supplemental Index
- Journal :
- Ecotoxicology & Environmental Safety
- Publication Type :
- Academic Journal
- Accession number :
- 150620009
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2021.112299