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Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys.
- Source :
- Environmental Pollution; Aug2021, Vol. 283, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- As ubiquitous, persistent organic pollutants, polycyclic aromatic hydrocarbons (PAHs) have adverse impacts on human health. Phenanthrene (Phe) is one of the most abundant PAHs in the environment. However, the long-term effects of exposure to environmental level of Phe on the kidneys and the potential mechanisms are unclear. T helper (Th) cells, a subtype of CD4<superscript> + </superscript> T cells that play a central role in the renal immune microenvironment. In this study, male mice were chronically exposed to 5, 50, and 500 ng/kg bw Phe every other day for total 210 days. Those results indicated that environmental Phe exposure caused kidney hypertrophy, injury and fibrosis in the mice. Chronic, long-term environmental level of Phe exposure did not significantly alter the innate immune response but induced adaptive immune response changes (Th1/Th2 related cytokines release), causing a type 1 immune response in the 5 ng/kg bw Phe group and a type 2 immune response in the high dose groups (50 and 500 ng/kg bw). This study provides novel insights into the roles of adaptive immune response in long-term PAH exposure-induced chronic kidney injury and fibrosis, which is beneficial for further understanding the potential health hazards of PAHs and providing new avenues for immune intervention strategies to alleviate PAHs toxicity. [Display omitted] • Environmental level of Phe chronic exposure causes kidney hypertrophy and fibrosis in mice. • Adaptive immune response regulates kidney hypertrophy and fibrosis. • Mitochondrial and ER dysfunction contributes to Phe-induced kidney hypertrophy and fibrosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02697491
- Volume :
- 283
- Database :
- Supplemental Index
- Journal :
- Environmental Pollution
- Publication Type :
- Academic Journal
- Accession number :
- 150792475
- Full Text :
- https://doi.org/10.1016/j.envpol.2021.117028