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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.
- Source :
- Cell Host & Microbe; Oct2021, Vol. 29 Issue 10, p1573-1573, 1p
- Publication Year :
- 2021
-
Abstract
- Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-cancer immunity and therapy response. Here, we identify Clostridiales members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Interestingly, these commensal species are also significantly reduced in CRC patients compared with healthy controls. Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8<superscript>+</superscript> T cells. Single application of Roseburia intestinalis or Anaerostipes caccae was even more effective than CC4. In a direct comparison, the CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma. Our findings provide a strong preclinical foundation for exploring gut bacteria as novel stand-alone therapy against solid tumors. [Display omitted] • Clostridiales bacteria are associated with low tumor burden in colon cancer models • Selected Clostridiales bacteria are diminished in colorectal cancer patients • A mix of Clostridiales strains have a potent anti-tumor effect via CD8<superscript>+</superscript> T cells • Clostridiales treatment is effective in solid tumors independently of anti-PD-1 Montalban-Arques et al. report that Clostridiales bacteria strains that are significantly reduced in colorectal cancer patients compared with healthy individuals are effective in driving a potent anti-tumor response in solid tumors. They demonstrate that this is via activation of CD8<superscript>+</superscript> T cells, independently of anti-PD-1 immunotherapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19313128
- Volume :
- 29
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Cell Host & Microbe
- Publication Type :
- Academic Journal
- Accession number :
- 152921110
- Full Text :
- https://doi.org/10.1016/j.chom.2021.08.001