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Effect of methanolic extract of Citrus limetta peel on cellular and humoral immune response in mice.
- Source :
- Pakistan Journal of Pharmaceutical Sciences; 2021 Supplement, Vol. 34, p1861-1866, 6p
- Publication Year :
- 2021
-
Abstract
- Citrus limetta is well known for its anti-inflammatory, antimicrobial, antifungal, antidiabetic and antioxidant properties. Methanolic extract of Citrus limetta (MECL) was used to assess cellular and humoral immune responses in mice by carrying out cyclophosphamide-induced neutropenia, delayed-type hypersensitivity (DTH), carbon clearance assay, haemagglutination assay (HA) and mice lethality assay. Methanolic extract of Citrus limetta peel was administered orally to mice in two doses 200mg/kg and 400mg/kg. The extract treated groups showed improvement in neutropenia induced by cyclophosphamide and improvement in the WBC profile. Skin thickness was significantly (P<0.05) higher in 200mg/kg and 400mg/kg groups in comparison to control in DTH. The phagocytic index was significantly (P<0.05) more in 400mg/kg group in carbon clearance assay. Mice were vaccinated with hemorrhagic septicemia vaccine before challenge with Pasteurella multocida for mice lethality test. Percentage mortality was decreased in 400mg/kg treated group in comparison to negative control Antibody titre response to sheep red blood cells was significantly (P<0.05) higher with dose 400mg/kg in HA. Results suggested the effectiveness of the methanolic extract of Citrus limetta as an immunostimulating agent. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1011601X
- Volume :
- 34
- Database :
- Supplemental Index
- Journal :
- Pakistan Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 153864281
- Full Text :
- https://doi.org/10.36721/PJPS.2021.34.5.SUP.1861-1866.1