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Next-generation sequencing for the genetic characterization of Maedi/Visna virus isolated from the northwest of China.
- Source :
- Journal of Veterinary Science; Nov2021, Vol. 22 Issue 6, p1-9, 9p
- Publication Year :
- 2021
-
Abstract
- Background: Maedi/Visna virus (MVV) is a contagious viral pathogen that causes considerable economic losses to the sheep industry worldwide. Objectives: In China, MVV has been detected in several regions, but its molecular characteristics and genetic variations were not thoroughly investigated. Methods: Therefore, in this study, we conducted next-generation sequencing on an MVV strain obtained from northwest China to reveal its genetic evolution via phylogenetic analysis. Results: A MVV strain obtained from Inner Mongolia (NM) of China was identified. Sequence analysis indicated that its whole-genome length is 9193 bp. Homology comparison of nucleotides between the NM strain and reference strains showed that the sequence homology of gag and env were 77.1%-86.8% and 67.7%-75.5%, respectively. Phylogenetic analysis revealed that the NM strain was closely related to the reference strains isolated from America, which belong to the A2 type. Notably, there were 5 amino acid insertions in variable region 4 and a highly variable motif at the C-terminal of the surface glycoprotein (SU5). Conclusions: The present study is the first to show the whole-genome sequence of an MVV obtained from China. The detailed analyses provide essential information for understanding the genetic characteristics of MVV, and the results enrich the MVV library. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC variation
SEQUENCE analysis
SHEEP industry
VIRUSES
AMINO acids
Subjects
Details
- Language :
- English
- ISSN :
- 1229845X
- Volume :
- 22
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Veterinary Science
- Publication Type :
- Academic Journal
- Accession number :
- 153886433
- Full Text :
- https://doi.org/10.4142/jvs.2021.22.e66