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Single nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in children.
- Source :
- CRANIO: The Journal of Craniomandibular & Sleep Practice; Mar2022, Vol. 40 Issue 2, p152-159, 8p
- Publication Year :
- 2022
-
Abstract
- Objective: To evaluate the association of bruxism phenotypes with single nucleotide polymorphisms in FKBP5, DRD2, ANKK1, and COMT.Methods: Clinical oral examination was performed to diagnose bruxism phenotypes in 150 children. DNA was collected from saliva. Logistic univariate regression, Chi-square, and Fisher's exact tests were performed (p < 0.05).Results: Bruxism was associated with DRD2 (p = 0.02). Tooth grinding while awake was associated with ANKK1 (p < 0.001), and tooth grinding while asleep was associated with DRD2 in the additive (p = 0.030) and dominant (p = 0.008) model. Tooth clenching while awake was associated with ANKK1 in the additive (p = 0.005) and dominant (p = 0.008) models, whereas tooth clenching while asleep was associated with ANKK1 (p < 0.001) and with COMT in the additive (p = 0.001) and dominant (p = 0.003) models.Discussion: Polymorphisms in DRD2, ANKK1, and COMT are associated with bruxism phenotypes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08869634
- Volume :
- 40
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- CRANIO: The Journal of Craniomandibular & Sleep Practice
- Publication Type :
- Academic Journal
- Accession number :
- 155550465
- Full Text :
- https://doi.org/10.1080/08869634.2019.1705629