Outcomes of laparoscopic sleeve gastrectomy with and without antrectomy in severely obese subjects. Evidence from randomized controlled trials.

Laparoscopic sleeve gastrectomy (SG) has been proven safe and effective in achieving weight loss. However, the distance from the pylorus where resection should begin has been debated. To compare the clinical outcomes of laparoscopic SG with antrum resection (AR) versus preservation (AP) for bariatric purposes by conducting a meta-analysis of randomized controlled trials (RCT). Academic hospital, United States. PubMed and Cochrane Library were queried for RCTs from establishment to August 2020. The following key search terms were used: "sleeve gastrectomy" AND ("antrectomy" OR "antrum") AND ("randomized" OR "random"). The following data were extracted: author, publication year, country, sample size, follow-up duration, and clinical outcomes, including weight-related: excess weight loss (EWL), total weight loss (TWL), body mass index (BMI), operation time, length of hospital stay, complication rates, and resolution of obesity-related comorbidities. A total of 9 unique RCTs including 492 AR and 385 AP patients were screened and included in the final quantitative analysis. Patients who underwent SG with AR showed higher EWL and TWL at 6 months (EWL: P <.001; TWL: P =.006), and 1 year (EWL: P =.013; P <.001) postoperatively. The BMI was also lower in the AR group 3 months (P =.013) and 6 months (P =.003) postoperatively. However, the EWL and BMI at 2 years were comparable between both groups (P =.222 and P =.908, respectively). No statistical significance was observed in terms of operating time, staple line disruption, bleeding, complications with a Clavien-Dindo Grade >III, resolution of comorbidities (hypertension, diabetes, hyperlipidemia, arthritis/back pain), and de novo gastroesophageal reflux disease (P >.05). AP was associated with a slightly shorter postoperative hospital stay (4.0 versus 3.1 days, P =.039). Laparoscopic SG with AR is associated with superior weight loss in the short-term compared with AP. However, mid-term follow-up beyond 1 year showed no significant differences in BMI or incidence of de novo gastroesophageal reflux disease. Based on evidence from randomized controlled trials, laparoscopic sleeve gastrectomy (LSG) with antrectomy is associated with superior short-term weight loss compared to LSG without antrectomy. Both procedures are equally effective in mid-term follow-up and beyond one year. Operating time, staple line disruption, bleeding, complications with Clavien-Dindo grade >3, resolution of comorbidities (hypertension, diabetes, hyperlipidemia, arthritis/back pain) and de novo gastroesophageal reflux disease were similar in both groups. Future randomized controlled trials with long-term results are warranted. [ABSTRACT FROM AUTHOR]