Back to Search
Start Over
The role of hyperinsulinaemia in screening for prediabetes in the adolescent population: A systematic literature review.
- Source :
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews; Apr2022, Vol. 16 Issue 4, pN.PAG-N.PAG, 1p
- Publication Year :
- 2022
-
Abstract
- Present screening methods for Type 2 diabetes (T2DM) fall short of detecting prediabetes. This paper summarises the literature on the utility of insulin measurements (hyperinsulinemia) in detecting prediabetes in adolescents. A systematic literature review was conducted using EMBASE and Medline. Relevant data on hyperinsulinemia in the adolescent population is narrated. The database search identified 174 potential articles; 106 underwent a full-paper review, and 36 were included. Elevated fasting insulin is a marker of impaired insulin resistance and pending beta-cell dysfunction in at-risk adolescents and can be an early indicator of prediabetes. • Prediabetes in adolescence involves insulin resistance, hyperinsulinaemia, beta-cell dysfunction and dysglycaemia. • Elevated fasting insulin is both reflective of insulin resistance and predictive of beta-cell dysfunction. • Further research should evaluate combining fasting insulin with glucose to screen for prediabetes in at-risk adolescents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18714021
- Volume :
- 16
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 156550200
- Full Text :
- https://doi.org/10.1016/j.dsx.2022.102445