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Viral cytopathic effect in maxillary sinus epithelium and SARS-CoV-2: Pitfalls in diagnostic characterization.
- Source :
- Journal of Oral Biology & Craniofacial Research; Jul2022, Vol. 12 Issue 4, p437-438, 2p
- Publication Year :
- 2022
-
Abstract
- Viral cytopathic effects (VCE) are a well-known phenomenon associated with SARS-CoV-2 infection, especially in the cells associated with the lungs. Because maxillary sinus epithelium expresses angiotensin-converting enzyme 2, cells associated with it are more likely to become infected with SARS-CoV-2 and develop VCE. If VCE is seen in with background of a confirmatory COVID-19 diagnosis, then connecting both become quite convincing. However, the diagnostic problem is expected when a similar VCE is seen without any confirmatory diagnosis of CODIV-19. We reported a biopsy sample of maxillary sinusitis in a COVID-19 negative patient. Histopathological examination revealed a pathognomonic VCE in the localized proliferating pseudostratified ciliated epithelium. The only confirmatory aspect linking this VCE with the SARS-CoV-2 was the detection of virus particles at the tissue level. In the present paper, pitfalls and recommendations for future research on this topic are discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124268
- Volume :
- 12
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Oral Biology & Craniofacial Research
- Publication Type :
- Academic Journal
- Accession number :
- 157439950
- Full Text :
- https://doi.org/10.1016/j.jobcr.2022.05.013