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Two new isocoumarins isolated from a mangrove-derived Penicillium sp.
- Source :
- Phytochemistry Letters; Aug2022, Vol. 50, p21-24, 4p
- Publication Year :
- 2022
-
Abstract
- Two new isocoumarins named peniciisocoumarins I and J (1 − 2), together with four known analogues (3 − 6), were obtained from Penicillium sp. GXIMD 03001, an endophytic fungus derived from the rhizophoraceous mangrove Kandelia candel. The structures and absolute configurations of 1 and 2 were determined by detailed analysis of their NMR, MS spectroscopic data, a modified Mosher's method and electronic circular dichroism data. All isolated isocoumarins were evaluated for their cytotoxic activity against four human cancer cell lines (SPCA-1, BEL-7402, GSC-7901 and MCF-7). However, none of the compounds exhibited any appreciable activity (IC 50 > 50 μ M). [Display omitted] • Two new isocoumarins, peniciisocoumarins I–J (1 and 2) were obtained from Penicillium sp. GXIMD 03001. • The absolute configuration of 1 was determined by a modified Mosher's ester method. • Cytotoxicity of all isolates against SPCA-1, BEL-7402, GSC-7901 and MCF-7 were examined. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18743900
- Volume :
- 50
- Database :
- Supplemental Index
- Journal :
- Phytochemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 157894712
- Full Text :
- https://doi.org/10.1016/j.phytol.2022.04.011