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Carbohydrate-based drugs launched during 2000−2021.

Authors :
Cao, Xin
Du, Xiaojing
Jiao, Heng
An, Quanlin
Chen, Ruoxue
Fang, Pengfei
Wang, Jing
Yu, Biao
Source :
Acta Pharmaceutica Sinica B; Oct2022, Vol. 12 Issue 10, p3783-3821, 39p
Publication Year :
2022

Abstract

Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as being involved in formating the genetic and energy materials, supporting the structure of organisms, constituting invasion and host defense systems, and forming antibiotics secondary metabolites. The naturally occurring carbohydrates and their derivatives have been extensively studied as therapeutic agents for the treatment of various diseases. During 2000 to 2021, totally 54 carbohydrate-based drugs which contain carbohydrate moities as the major structural units have been approved as drugs or diagnostic agents. Here we provide a comprehensive review on the chemical structures, activities, and clinical trial results of these carbohydrate-based drugs, which are categorized by their indications into antiviral drugs, antibacterial/antiparasitic drugs, anticancer drugs, antidiabetics drugs, cardiovascular drugs, nervous system drugs, and other agents. A systemic review of the total 54 carbohydrate-based drugs, which approved during 2000–2021, is comprehensively summarized according to their chemical structures, activities, and clinical trial results. [Display omitted] [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22113835
Volume :
12
Issue :
10
Database :
Supplemental Index
Journal :
Acta Pharmaceutica Sinica B
Publication Type :
Academic Journal
Accession number :
159355875
Full Text :
https://doi.org/10.1016/j.apsb.2022.05.020