Activity of Matrix Metalloproteinases (Mmps) Production by Dentine Matrix Depending on The Used Adhesive System: A Systematic Review.

Matrix metalloproteinases (MMPs) are a group of enzymes that are correlated with the degradation of the hybrid layer. This article describes the effect of adhesive systems on the MMPs. A systematic review of the literature was conducted analyzing articles published on PubMed, Google scholar, Scopus, ResearchGate and ScienceDirect between 2011 and 2021, activity of the MMPs was the selected outcome variable. A total of 22 publications were selected, 9 of which were selected for detailed review. Chief question in this article was: which generation of adhesive systems has more effect on MMPs? How does it affect them? Etch-and rinse adhesive systems showed higher level gelatinolytic activity, when compared to Self-etch adhesive systems. Activation of the MMPs is due in most adhesive systems, which is responsible for the degradation of the hybrid layer. Etch-and-rinse adhesive systems showed higher gelatinolytic activity when compared to self-etch adhesive systems, further studies are needed on new chemicals capable of inhibiting MMP activity. Moreover, further studies are needed to check MMP activity in non-vital teeth. [ABSTRACT FROM AUTHOR]