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B vitamin intakes modify the association between particulate air pollutants and incidence of all‐cause dementia: Findings from the Women's Health Initiative Memory Study.
- Source :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Nov2022, Vol. 18 Issue 11, p2188-2198, 11p
- Publication Year :
- 2022
-
Abstract
- Introduction: Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B12, and B6) modified the association between PM2.5 exposure and incidence of all‐cause dementia. Methods: This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3‐year average PM2.5 exposure was estimated using a spatiotemporal model. Results: During a mean follow‐up of 9 years, 342 participants developed all‐cause dementia. We found that residing in locations with PM2.5 exposure above the regulatory standard (12 μg/m3) was associated with a higher risk of dementia only among participants with lower intakes of these B vitamins. Discussion: This is the first study suggesting that the putative neurotoxicity of PM2.5 exposure may be attenuated by high B vitamin intakes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15525260
- Volume :
- 18
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 160260600
- Full Text :
- https://doi.org/10.1002/alz.12515