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3-MCPD exposure enhances ovarian fibrosis and reduces oocyte quality in mice.
- Source :
- Environmental Pollution; Jan2023:Part 2, Vol. 316, pN.PAG-N.PAG, 1p
- Publication Year :
- 2023
-
Abstract
- 3-monochloro-1,2-propanediol (3-MCPD) is a food contaminant believed to be harmful to human health. Previous studies showed that 3-MCPD exerts toxic effects in multiple tissues, but whether 3-MCPD affects female reproductive function remained unknown. Here, using mouse gastric lavage models, we report that 3-MCPD exposure for four weeks affected body growth, decreased the ovary/body weight ratio, and increased atretic follicle numbers. Expression levels of follicular development-related factors decreased. Further studies found that ovaries from 3-MCPD exposed mice had activated the Transforming Growth Factor-β (TGF-β) signaling pathway and promoted ovarian fibrosis. Increased TNF-α, IL-1 and NF-κB expression also indicated the occurrence of ovarian inflammation. Exposure to 3-MCPD stimulated the caspase pathway and enhanced granulosa cell apoptosis. Consistent with disrupted ovarian homeostasis, 3-MCPD exposure interfered with mitochondrial function, generated more reactive oxygen species, increased ferrous ion and lipid peroxidation levels, and resulted in decreased oocyte development potential. Collectively, these findings indicated that 3-MCPD exposure induced ovarian inflammation and fibrosis, and caused disorders of mitochondrial function and ferrous ion homeostasis in oocytes, which consequently disturbed follicle maturation and reduced oocyte quality. [Display omitted] • 3-MCPD exposure impaires mouse follicular development. • 3-MCPD exposure induces ovary fibrosis, inflammation and apoptosis. • 3-MCPD exposure decrease oocyte quality through oxidative stress. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02697491
- Volume :
- 316
- Database :
- Supplemental Index
- Journal :
- Environmental Pollution
- Publication Type :
- Academic Journal
- Accession number :
- 160632362
- Full Text :
- https://doi.org/10.1016/j.envpol.2022.120662