Bibliometric Analysis of Studies Related to the Regulation of Exercise on Muscle, Liver and Lipid Exerkines.

Objective: To perform visual analysis of the related researches on exercise regulation of muscle, liver, and lipid exerkines, and discuss the research hotspots and frontiers in this field. Methods: The data source is the relevant research literature on exercise regulation of muscle, liver, and lipid exerkines included in the core databases of "Web of Science" and "CNKI" from 2004 to 2020. Scientific knowledge map is drawn with the help of "CNKI" visual analysis function and "Cite Space V" software. Results: 1) A total of 166 domestic papers were included on relevant research, showing a slow upward trend on the whole. The main research hotspots are the regulation of adipokines by aerobic exercise to improve insulin resistance, the effects of different exercise modes and loads on the expression of muscle, liver, and lipid exerkines, and regulatory effects of muscle, liver and lipid exerkines on metabolic diseases. 2) A total of 632 overseas papers were included on relevant research, which are still in the initial stage of development. The United States ranks first with 156 papers, and the cooperation between countries is relatively simple. Frontiers in Physiology is the journal with the most publications (19 articles). Productive authors and teams are concentrated in the Federal University of Sao Paulo, Brazil. The research frontier keywords are activation, irisin and biomarker. The research hotspots mainly focus on the effects of exercise-regulated muscle, liver and lipid exerkines on obesity, the effects of exercise-regulated muscle, liver and lipid exerkines on cardiovascular diseases, and the effects of aerobic exercise on the regulation of myokines on brain function. Conclusion: Aerobic exercise can regulate the expression of adipokines and improve insulin sensitivity; different exercise programs can regulate the differential expression of muscle, liver and lipid exerkines; muscle, liver and lipid exerkines can reduce the risk factors of metabolic diseases. Exercise can up regulate leptin expression and regulate TNF- a Level, improve obesity, mediate muscle, liver and lipid ex-erkines, inhibits cell apoptosis, and alleviates the process of cardiovascular disease, and improve the expression of myokines to improve brain function. In the future, it is necessary to enhance the depth and cooperation density of research on exerc.ise regulation of muscle, liver and lipid exerkines, strengthen the research on the mechanism of muscle, liver and lipid exerkines to prevent and treat metabolic diseases such as diabetes, obesity, cardiovascular disease and brain disease, explore the exact exercise program for the best effect of muscle, liver and lipid exerkines and its new type of biomarkers fur detection and prognosis diagnosis, and systematically sort out the relevant signal pathways that exercise regulates muscle, liver and lipid exerkines and diseases. [ABSTRACT FROM AUTHOR]