Preoperative oral probiotics relieve insulin resistance and gut dysbacteriosis in patients with gastric cancer after gastrectomy.

[Display omitted] • Prophylactic use of probiotics before gastrectomy reduces inflammatory responses in patients. • Prophylactic administration of probiotics before gastrectomy can alleviate postoperative insulin resistance in patients. • A possible mechanism by which probiotic use of probiotics accelerates postoperative recovery in patients with gastric cancer after gastrectomy is to restore gut microbiota balance. Gastrectomy can improve the clinical survival rate of gastric cancer patients, while the metabolic disorders caused by gastrectomy, seriously affect the postoperative recovery. In this study, probiotics (including Bifidobacterium infantis , Lactobacillus acidophilus , Enterococcus faecalis and Bacillus cereus) were used before gastrectomy to explore the effect of probiotics on gastrectomy patients. Our outcomes revealed probiotics could alleviate postoperative inflammation (Leukocyte; P < 0.05), improve the metabolic disorder (fasting glucose; fasting insulin; HOMA-IR; P < 0.05), reduce the incidence of postoperative insulin resistance (IR; P < 0.001) and infectious complications (P < 0.05). Besides, the probiotics greatly enriched the relative abundance of bacteria Faecalibacterium prausnitzii and Gemmiger formicilis , while decreased the pathogenic Bacteroides fragilis , Prevotella copri and Clostridium difficile at the species levels. Therefore, we believe that preventive use of probiotics can reduce postoperative inflammation, alleviate metabolic disorder, reduce insulin resistance, restore intestinal microecological balance, and finally promote early recovery of patients. [ABSTRACT FROM AUTHOR]