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Associations of grip strength, walking pace, and the risk of incident dementia: A prospective cohort study of 340212 participants.
- Source :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Apr2023, Vol. 19 Issue 4, p1415-1427, 13p
- Publication Year :
- 2023
-
Abstract
- Introduction: Grip strength and walking pace have been linked to cognitive dysfunction. Their relationships, however, demand further clarification as the evidence is derived primarily from less‐comprehensive investigations. Methods: A total of 340212 UK Biobank participants without dementia and cardiovascular diseases at baseline were analyzed. Cox proportional hazard models assessed the longitudinal associations. Results: Over a mean follow‐up of 8.51 ± 2.68 years, 2424 incident dementia cases were documented. A 5 kg increment of absolute grip strength was associated with lower risks of all‐cause dementia (hazard ratio [HR] 0.857), Alzheimer's disease (HR 0.874), and vascular dementia (HR 0.788). The patterns of associations remained similar when grip strength was expressed in relative terms and quintiles. A slow walking pace demonstrated consistent associations with increased risks of all dementia types. Discussion: Our findings provide amplified evidence and suggest that muscle fitness, reflected by objective grip strength measures and self‐reported walking pace, may be imperative for estimating the risks of dementia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15525260
- Volume :
- 19
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 163092128
- Full Text :
- https://doi.org/10.1002/alz.12793