Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome.

Keywords: Amiloride Therapy; Asia; Blood Pressure; Cardiovascular Agents; Cardiovascular Diseases and Conditions; China; Diuretics; Drugs and Therapies; Genetics; Health and Medicine; Hemodynamics; Hypertension; Inborn Errors Renal Tubular Transport; Liddle's Syndrome; Nutritional and Metabolic Diseases and Conditions; Pharmaceuticals; Potassium-Sparing Diuretics; Science China Press EN Amiloride Therapy Asia Blood Pressure Cardiovascular Agents Cardiovascular Diseases and Conditions China Diuretics Drugs and Therapies Genetics Health and Medicine Hemodynamics Hypertension Inborn Errors Renal Tubular Transport Liddle's Syndrome Nutritional and Metabolic Diseases and Conditions Pharmaceuticals Potassium-Sparing Diuretics Science China Press 338 338 1 05/29/23 20230602 NES 230602 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Hypertension is a cardiovascular disease that seriously threatens global public health. Liddle syndrome (LS) is an autosomal dominant monogenic hypertension characterized by early-onset hypertension, hypokalemia, hypoaldosteronism, and low plasma renin. [Extracted from the article]