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EP035 DEBRIDEMENT WITH TOPICAL DESICCATION AGENT IN THE TREATMENT OF ULCERATIVE (WAGNER III AND IV) LESIONS OF THE DIABETIC FOOT: A CASE SERIES OF TWENTY PATIENTS.

Authors :
Hermans, Michel
Bruttocao, A.
Source :
Journal of Wound Management; Jul2023, Vol. 24 Issue 2, p51-51, 1/2p
Publication Year :
2023

Abstract

Aim: Diabetic foot ulcers, particularly those with high Wagner scores, are difficult to heal. They are, per definition, infected and patients in this category typically also suffer from serious comorbidities. TDA* is an innovative debriding agent that works via topical desiccation of necrosis and biofilm through a hygroscopic action. This results in the denaturing of their proteins and, typically, a rapid sloughing off. Efficacy of TDA was evaluated in patients with Wagner III and IV diabetic foot ulcers with culture-confirmed colonization of multidrug-resistant Pseudomonas Aeruginosa. Method: TDA was applied for 60 second and rinsed of, followed by the application of standard dressings. Study participation was limited to 40 days. Results / Discussion: The average age of patients was 74+12.2 years. Average ulcer (N=20) size was 9.1+7.6 cm2. 16 of 20 patients (75%) were revascularized prior to the initiation of TDA. Five patients (25%) were on hemodialysis, and all were on anticoagulant or antiplatelet therapy. Within the maximum observation period of 40 days, improvement of the wound occurred in 17 of 20 (85%) cases. Size reduction was noted in 16 of 20 patients (80%) and six of the 20 ulcers (30%) healed completely. Two ulcers (10%) were unchanged at 40 days and one ulcer (5%) worsened, probably due to poor compliance. Conclusion: Wagner III and IV diabetic ulcers were treated with TDA as the primary debridement agent. In spite of the complexity and seriousness of the lesions, all but three showed considerable improvement or complete healing within the study period of 49 days. * Debrichem, DEBx, the Netherlands [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
27885771
Volume :
24
Issue :
2
Database :
Supplemental Index
Journal :
Journal of Wound Management
Publication Type :
Academic Journal
Accession number :
164968752