Bcl-2 and Bcl-X-L inhibitor proved effective against diffuse large cell lymphoma.

This article presents findings of a research on large scale lymphoma conducted by R.M. Mohammad and published in the journal "Molecular Cancer Therapeutics." A small-molecule inhibitor of Bcl-2 and Bcl-X-L proteins is proven effective against diffuse large cell lymphoma. Diffuse large cell lymphoma is the most common subtype of non-Hodgkin lymphoma. Gossypol, a natural product isolated from cottonseeds, was discovered as a potent small-molecule inhibitor of Bcl-2 and Bcl-X-L proteins. Using WSU-DLCL2-SCID mouse xenograft model, the tumor growth inhibition, the tumor growth delay, and the log[10] kill of mice treated with (-)-gossypol + CHOP were better than 2/Bcl-X-L small-molecule inhibitor to standard chemotherapy may prove an effective strategy in lymphoma therapy