Circulating CD26 analyzed, influence on arthritic inflammation clarified.

The article cites a study on arthritic inflammation, by N. Busso and colleagues, and published in the "American Journal of Pathology." According to a study, circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Dipeptidyl peptidase IV, a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and nonimmune cell types. Decreased circulating CD26 levels in arthritis may influence CD26- mediated regulation of the chemotactic SDF-1/CXCR4 axis.