Researchers' Work from University of North Carolina Focuses on Science (A Genome-wide Crispr-cas9 Knockout Screen Identifies Fsp1 As the Warfarin-resistant Vitamin K Reductase).

Keywords: Chapel Hill; State:North Carolina; United States; North and Central America; Science; Coenzymes; Diet and Nutrition; Enzymes and Coenzymes; Genetics; Health and Medicine; Reductase; Ubiquinone; Vitamin K; Vitamins EN Chapel Hill State:North Carolina United States North and Central America Science Coenzymes Diet and Nutrition Enzymes and Coenzymes Genetics Health and Medicine Reductase Ubiquinone Vitamin K Vitamins 1693 1693 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Science. Here, we report the identification of warfarin-resistant vitamin K reductase using a genome-wide CRISPR-Cas9 knockout screen with a vitamin K-dependent apoptotic reporter cell line. Patients overdosed on warfarin can be rescued by administering high doses of vitamin K because of the existence of a warfarin-resistant vitamin K reductase. [Extracted from the article]