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Exposure to okadaic acid could disrupt the colonic microenvironment in rats.
- Source :
- Ecotoxicology & Environmental Safety; Sep2023, Vol. 263, pN.PAG-N.PAG, 1p
- Publication Year :
- 2023
-
Abstract
- Okadaic acid (OA) is one of the most prevalent marine phycotoxin with complex toxicity, which can lead to toxic symptoms such as diarrhea, vomiting, nausea, abdominal pain, and gastrointestinal discomfort. Studies have shown that the main affected tissue of OA is digestive tract. However, its toxic mechanism is not yet fully understood. In this study, we investigated the changes that occurred in the epithelial microenvironment following OA exposure, including the epithelial barrier and gut bacteria. We found that impaired epithelial cell junctions, mucus layer destruction, cytoskeletal remodeling, and increased bacterial invasion occurred in colon of rats after OA exposure. At the same time, the gut bacteria decreased in the abundance of beneficial bacteria and increased in the abundance of pathogenic bacteria, and there was a significant negative correlation between the abundance of pathogenic bacteria represented by Escherichia/Shigella and animal body weight. Metagenomic analysis inferred that Escherichia coli and Shigella spp. in Escherichia/Shigella may be involved in the process of cytoskeletal remodeling and mucosal layer damage caused by OA. Although more evidence is needed, our results suggest that opportunistic pathogens may be involved in the complex toxicity of OA during OA-induced epithelial barrier damage. [Display omitted] • OA exposure interfered the colonic epithelial microenvironment. • OA exposure disrupted the epithelial barrier and gut bacterial composition. • Disrupted colonic epithelial barrier is accompanied by increased bacterial invasion. • Invaded pathogens may complicate the oral toxicity of OA in rats. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01476513
- Volume :
- 263
- Database :
- Supplemental Index
- Journal :
- Ecotoxicology & Environmental Safety
- Publication Type :
- Academic Journal
- Accession number :
- 171954637
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2023.115376