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Nocturnal High-Flow Nasal Cannula Therapy and Sinonasal Symptoms During Cystic Fibrosis Exacerbations.
- Source :
- Respiratory Care; Nov2023, Vol. 68 Issue 11, p1527-1531, 5p
- Publication Year :
- 2023
-
Abstract
- BACKGROUND: Both nasal obstruction and sleep disturbance are common in patients with cystic fibrosis (CF). In patients with obstructive sleep apnea (OSA), studies suggest that these conditions are related and that nasal congestion improves with CPAP therapy. We hypothesized that subjects admitted to hospital for therapy of an exacerbation of CF would have both nasal symptoms and sleep disturbance and that these would improve with the initiation of nocturnal high-flow nasal cannula therapy (HFNC). METHODS: Twenty-five subjects with an exacerbation of CF were enrolled to randomly receive either 5 d of nocturnal HFNC at 20 L/min in the treatment group or 5 L/min of nocturnal nasal cannula air at ambient temperature and humidity in the low-flow group. On the first and last day of the study, the Sino-Nasal Outcome Test (SNOT-20) was administered to evaluate nasal symptoms, and sleep quality was measured using the Actiwatch 2. RESULTS: Fifteen subjects completed the study (6 HFNC, 9 low flow). We confirmed that subjects had significant sleep disturbance that did not improve over the 5 d of the study. Subjects also had disturbing nasal symptoms that significantly improved only in those receiving HFNC (pre 14 [20] vs post 6 [13], P 5 .027). CONCLUSIONS: Similar to what has been reported in older subjects with OSA, nocturnal HFNC improves sinonasal symptoms in subjects with an exacerbation of CF. There was no measurable effect on sleep quality, which may be due to the short duration of the study, or to subjects being evaluated while being treated in a hospital setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYSTIC fibrosis treatment
SLEEP apnea syndrome treatment
TREATMENT of respiratory obstructions
SLEEP quality
PILOT projects
NASAL cannula
CONTINUOUS positive airway pressure
MANN Whitney U Test
NOSE
TREATMENT effectiveness
RANDOMIZED controlled trials
T-test (Statistics)
HIGH-frequency ventilation (Therapy)
OXYGEN therapy
DESCRIPTIVE statistics
QUALITY of life
STATISTICAL sampling
DATA analysis software
DISEASE exacerbation
DROWSINESS
Subjects
Details
- Language :
- English
- ISSN :
- 00201324
- Volume :
- 68
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Respiratory Care
- Publication Type :
- Academic Journal
- Accession number :
- 173202163
- Full Text :
- https://doi.org/10.4187/respcare.09890