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Subcutaneous Treprostinil Improves Surgical Candidacy for Next Stage Palliation in Single Ventricle Patients With High-Risk Hemodynamics.

Authors :
Sullivan, Rachel T.
Handler, Stephanie S.
Feinstein, Jeffrey A.
Ogawa, Michelle
Liu, Esther
Ma, Michael
Hopper, Rachel K.
Norris, Jana
Hollander, Seth A.
Chen, Sharon
Source :
Seminars in Thoracic & Cardiovascular Surgery; Winter2023, Vol. 35 Issue 4, p733-743, 11p
Publication Year :
2023

Abstract

Single ventricle (SV) patients with pulmonary vascular disease (SV-PVD) are considered poor surgical candidates for Glenn or Fontan palliation. Given limited options for Stage 1 (S1) and Stage 2 (S2) SV patients with SV-PVD, we report on the use of subcutaneous treprostinil (TRE) to treat SV-PVD in this population. This single-center, retrospective cohort study examined SV patients who were not candidates for subsequent surgical palliation due to SV-PVD and were treated with TRE. The primary outcome was ability to progress to the next surgical stage; secondary outcomes included changes in hemodynamics after TRE initiation. Between 3/2014 and 8/2021, 17 SV patients received TRE for SV-PVD: 11 after S1 and 6 after S2 (median PVR 4.1 [IQR 3.2–4.8] WU*m<superscript>2</superscript> and 5.0 [IQR 1.5–6.1] WU*m<superscript>2</superscript>, respectively). Nine of 11 (82%) S1 progressed to S2, and 2 (18%) underwent heart transplant (HTx). Three of 6 (50%) S2 progressed to Fontan, 1 underwent HTx and 2 are awaiting Fontan on TRE. TRE significantly decreased PVR in S1 patients with median post-treatment PVR of 2.0 (IQR 1.5–2.6) WU*m<superscript>2</superscript>. TRE can allow for further surgical palliation in select pre-Fontan patients with SV-PVD, obviating the need for HTx. Improvement in PVR was significant in S1 patients and persisted beyond discontinuation of therapy for most patients. [Display omitted] [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10430679
Volume :
35
Issue :
4
Database :
Supplemental Index
Journal :
Seminars in Thoracic & Cardiovascular Surgery
Publication Type :
Academic Journal
Accession number :
173852505
Full Text :
https://doi.org/10.1053/j.semtcvs.2022.07.011