Research Data from Jackson Laboratory Update Understanding of Immunosuppressants [Astaxanthin and Meclizine Extend Lifespan In Um-het3 Male Mice; Fisetin, Sg1002 (Hydrogen Sulfide Donor), Dimethyl Fumarate, Mycophenolic Acid, and...].

A recent study conducted at the Jackson Laboratory in Bar Harbor, Maine, has found that the Nrf2 activator astaxanthin and the mTORC1 inhibitor meclizine can extend the lifespan of male mice by 12% and 8% respectively. However, these effects were not significant in females. The study also tested five other agents, including fisetin and dimethyl fumarate, but found no significant lifespan effects. The researchers suggest that these findings may provide insights into sex-specific aspects of aging. The study was supported by the NIH National Institute on Aging, the Glenn Foundation for Medical Research, and the US Department of Veterans Affairs. [Extracted from the article]