Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechanotransduction.

Primary cilia, which are cell surface extensions, play a crucial role in the development and mechanosensation of various tissues, including bone. This study examined the role of primary cilia in bone growth and adaptation by analyzing two specific genes, IFT88 and MKS5, that are necessary for proper cilia assembly and function. The study found that the absence of primary cilia in osteoblasts led to a decrease in body weight and shorter femurs in mice. Additionally, the absence of primary cilia in osteocytes resulted in a decreased response to mechanical loading and reduced bone formation. These findings highlight the importance of primary cilia in skeletal development and mechanotransduction. [Extracted from the article]