Unbalanced form of translocation deletion between chromosomes 6 and 22 in a mentally handicapped female [45,XX,-6,-22,+der(6),t(6;22) (q25.1:q11.2)].

The article presents the case report of a mentally handicapped female with unbalanced form of translocation deletion between chromosomes 6 and 22. Her general appearance is rather masculine. She is microcephalic, with a sloping short forehead, some bossing of frontal bones and flattened occiput with a low hairline. Orbital ridges are prominent with bushy eyebrows meeting at the mid-line. The clinical manifestations in this patient appear to be the result of partial deletion of the long arm of chromosome 6.