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Chlordane exposure impairs the growth and behavior of Drosophila.

Authors :
Li, Boyang
Chen, Luxi
Li, Feng
Cao, Qiaoyao
Yan, Chenyan
Wu, Xin
Wang, Kexin
Wu, Mingjiang
Gao, Yitian
Tong, Haibin
Source :
Ecotoxicology & Environmental Safety; Jan2024, Vol. 270, pN.PAG-N.PAG, 1p
Publication Year :
2024

Abstract

Chlordane, a previously extensively utilized insecticidal pesticide, has since been prohibited, however, owing to its limited degradability, it continues to persist significantly in soil and water reservoirs, subsequently accumulating within plant and animal organisms, representing a substantial threat to human health. Despite extensive research conducted over the past few decades to investigate the toxic effects of chlordane, there remains a notable dearth of studies focusing on its impact on sleep activity. Therefore, in this study, the effects of short-term and long-term exposure to chlordane on the activity and sleep of Drosophila were investigated. When exposed to chlordane at a concentration of 1 μM, Drosophila lost body weight, decreased body size and resulted in lipid metabolism disorders. In addition, chlordane exposure altered the arousal and sleep behaviors of Drosophila. Short-term exposure to chlordane resulted in an increase in night-time sleep duration, while long-term exposure to chlordane resulted in an increase in activity and a decrease in sleep, as evidenced by a decrease in the duration of each sleep session and the appearance of sleep fragmentation. Under conditions of long-term chlordane exposure, reactive oxygen species levels were significantly up-regulated in Drosophila. Our results suggest that long-term chlordane exposure triggers oxidative stress damage in Drosophila , leading to sleep disruption. This study offers novel insights into the harmful impacts of environmental pollutants on human sleep patterns and proposes that mitigating the presence of chlordane in the environment could potentially contribute to the reduction of global sleep disorder prevalence. • Long-term chlordane exposure induces growth inhibition in Drosophila. • Chlordane exposure disrupts lipid metabolism in Drosophila. • Short-term chlordane exposure increases nighttime sleep duration. • Long-term chlordane exposure induces fragmented sleep patterns and mild hyperactivity in Drosophila. • Chronic chlordane exposure upregulates 4-HNE and increases oxidative stress levels [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01476513
Volume :
270
Database :
Supplemental Index
Journal :
Ecotoxicology & Environmental Safety
Publication Type :
Academic Journal
Accession number :
174914701
Full Text :
https://doi.org/10.1016/j.ecoenv.2023.115903