Reports Outline Mastocytosis Study Findings from University of Texas MD Anderson Cancer Center (Multicolor flow cytometric immunophenotyping is highly sensitive and specific in identifying aberrant mast cells in the diagnostic workup of...).

A recent report from the University of Texas MD Anderson Cancer Center highlights the diagnostic utility of flow cytometric immunophenotyping (FCI) in identifying mastocytosis, a condition characterized by abnormal mast cells. The study found that FCI was able to detect immunophenotypic aberrancies in 100% of systemic mastocytosis (SM) cases, with CD2, CD25, and CD30 being important markers for identifying these abnormalities. The research also revealed differences in aberrancy frequencies across different subtypes of SM. The findings suggest that FCI is a quick and sensitive tool for evaluating mast cell immunophenotypes, and abnormal FCI results should prompt further histologic evaluation and mutation testing. [Extracted from the article]