Reports on Cholera from University of California San Francisco (UCSF) Provide New Insights (Mg2+supplementation Treats Secretory Diarrhea In Mice By Activating Calcium-sensing Receptor In Intestinal Epithelial Cells).

A report from the University of California San Francisco (UCSF) discusses new research findings on cholera, a global health problem with no targeted therapies. The study focuses on the role of the calcium-sensing receptor (CaSR) in treating diarrhea, which is a symptom of cholera. The researchers found that magnesium (Mg2+) supplementation activates the CaSR in intestinal epithelial cells, leading to a reduction in chloride secretion and fluid accumulation. This suggests that oral Mg2+ supplementation could be a potential therapy for cholera and other secretory diarrheas. [Extracted from the article]