New Findings on Endometriosis Described by Investigators at Capital Medical University (Metformin Inhibits the Estrogen-mediated Epithelial-mesenchymal Transition of Ectopic Endometrial Stromal Cells In Endometriosis).

A recent report discusses new research on endometriosis conducted by investigators at Capital Medical University in Beijing, China. The study focuses on the role of endometrial stromal cells (ESCs) in the development of endometriosis, an estrogen-dependent disease characterized by the growth of endometrial tissue outside the uterus. The researchers found that metformin, a medication commonly used to treat diabetes, inhibited the proliferation, migration, and invasion of ectopic ESCs in a dose-dependent manner. Additionally, metformin downregulated the expression of certain markers associated with epithelial-mesenchymal transition (EMT) and reduced the expression and nuclear translocation of ß-catenin in EESCs. These findings suggest that metformin may have therapeutic potential for endometriosis. [Extracted from the article]