Wageningen University and Research Researchers Detail Findings in Immunoglobulins [Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells].

Researchers from Wageningen University and Research have conducted a study on the immunotoxic effects of perfluoralkylsubstances (PFASs), which are associated with adverse health effects. The study focused on the effects of 15 PFASs on gene expression in human B lymphoma and T cells. The results showed that certain PFASs, such as HFPO-TA and PFDA, had a significant impact on gene expression and may impair the generation of diverse B cells and T cell activation, leading to a reduced antibody response. The study provides insights into the mechanisms behind PFAS-induced immunotoxicity and suggests that the in vitro models used in the study can be useful for assessing the immunotoxic potential of PFASs. [Extracted from the article]