Studies from Ocean University of China Yield New Information about Nanoparticles (Nanoparticles Traversing the Extracellular Matrix Induce Biophysical Perturbation of Fibronectin Depicted By Surface Chemistry).

A study conducted by researchers at the Ocean University of China explores the interactions between nanoparticles (NPs) and fibronectin (Fn), a component of the extracellular matrix (ECM) that is important for cell attachment and signaling. The researchers used molecular dynamics simulations to investigate the effects of different types of NPs on the cell-binding domains of Fn. The results showed that NPs can bind to specific Fn domains and that the strength of these interactions depends on the physicochemical properties of the NPs. The study provides valuable insights into the impacts of NPs on the ECM and has implications for nanomedicine and nanosafety evaluation. [Extracted from the article]