Recent Studies from University of Connecticut Add New Data to Gene Therapy (Nfe2l3 Promotes Neuroprotection and Long-distance Axon Regeneration After Injury In Vivo).

A recent study conducted at the University of Connecticut has found that the Nfe2l3 gene promotes neuroprotection and long-distance axon regeneration after central nervous system (CNS) injury. The researchers evaluated the expression of Nfe2l3 in cortical and retinal ganglion cell neurons and found that it is primarily expressed in developing immature neurons and not upregulated after injury. However, when Nfe2l3 was expressed in injured retinal ganglion cells through viral vector delivery, it promoted neuroprotection and axon regeneration. This research suggests that Nfe2l3 could be a potential therapeutic target for treating CNS injury and disease. [Extracted from the article]